Provided herein are isotopically enriched arylsulfonamides, for example, of Formula I, that are useful for modulating CCR3 activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a CCR3-mediated disease, disorder, or condition.本文提供適用於調節CCR3活性之例如式I之富含同位素之芳磺醯胺及其醫藥組合物。本文亦提供其用於治療、預防或改善CCR3介導之疾病、病症或病狀之一或多種症狀的方法