Michael K. Riscoe,Jane X. Kelly,Rolf W. Winter,David J. Hinrichs,Martin J. Smilkstein,Aaron Nilsen,Jeremy Burrows,Dennis Kyle,Roman Manetsch,Richard M. Cross,Andrii Monastyrskyi,David L. Flanigan
申请号：
US13153350
公开号：
US20120115904A1
申请日:
2011.06.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compounds of formula I:or formula II:or a pharmaceutically acceptable salt of formula I or formula II, wherein: R1 is H, hydroxyl, alkoxy, acyl, alkyl, cycloalkyl, aryl, or heteroaryl R2 is methyl or haloalkyl R4 is hydroxyl, carbonyloxy, or carbonyldioxy and R3 is aliphatic, aryl, aralkyl, or alkylaryl and R5, R6, R7 and R8 are each individually H, halogen, alkoxy, alkyl, haloalkyl, aryl, nitro, cyano, amino, amido, acyl, carboxyl, substituted carboxyl, or —SO2R10, wherein R10 is H, alkyl, amino or haloalkyl provided that in formula I, R5 and R are not both H or R6 is not H or methoxy and in formula II that if R4 is carbonyldioxy then R7 is not methoxy.
