Compositions and methods are described for vaccinating against E. coli urinary tract infections. The compositions comprise a FimH polypeptide, one or more conjugates comprising E. coli O-antigens polysaccharide covalently coupled to a carrier protein, and an adjuvant.描述了用於針對大腸桿菌尿路感染進行疫苗接種之組成物和方法。該等組成物包含FimH多肽、一種或多種包含與載體蛋白共價偶合的大腸桿菌O-抗原多糖的軛合物、和佐劑。