The present invention relates, e.g., to a system for treating damaged skin, comprising a cosmeceutical formulation comprising a. an about 1-10% mixture of perfluorocarbons (PFC's) of at least three different molecular weights, and b. about 0.001-5% hyaluronic acid (HA) of molecular weight about 100 kDa or less, packaged in an aerosol spray container. In embodiments of the invention, the cosmeceutical formulation is aqueous, or it comprises an oil and water emulsion, comprising about 80% purified water and about 10% components of an oil phase. Also disclosed are methods of using this system to treat damaged skin, or to prevent the damage of skin from, e.g., wounds or aging.