Method of preparing a Collagen gel crosslinked by Irradiation of radiation includes Radiation to obtain Liquid Collagen cross-linked Collagen； Collagen gel； and use.
YU, JI CHUL,YEO, SE KEN,KIM, TAI HYOUNG,SHU, DONG SAM,CHANG, CHEONG HO
申请号：
CL2013001999
公开号：
CL2013001999A1
申请日:
2013.07.08
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The present invention relates to radiation cross-linked collagen gel, and a preparation method and usage method thereof. To this end, the present invention comprises a cross-linked collagen material made by irradiating liquid collagen with radioactive rays, wherein the concentration of said collagen is specifically 0.1-10% (W/V), and the radiation dose (dose rate X time) is 0.1 - 40 kGy on the basis of 1 kGy/hr. The present invention configured as above can prepare a formulated collagen gel using a physical cross-linking method instead of a chemical cross-linking method, specifically carries out the formulation by mixing biocompatible materials, and provides a method capable of using a cross-linked collagen hydrogel in wound dressings, graft materials, cell cultures and the like. Therefore, the present invention provides an industrially convenient and safe preparation method, thereby instilling a good image to a customer by greatly improving the quality and confidence in the products.<；p>；Mé；todo de preparació；n de un gel de colá；geno reticulado por radiació；n, que comprende la irradiació；n del colá；geno lí；quido con radiació；n para así； obtener un colá；geno reticulado, donde la concentració；n de colá；geno en el colá；geno lí；quido es de entre 0,1 y 10% (p/v) y la dosis (í；ndice de dosis x tiempo) de radiació；n es de entre 0,1 y 40 kGy/hr, el mé；todo comprende mezclar 3% (p/v) de colá；geno con 3% (p/v) de polí；mero sinté；tico Pluronic F-127, 1% (p/v) de PEO (ó；xido de polietileno) (MW=100.000) y 3% (p/v) de hidroxiapatita y reticular la mezcla mediante irradiació；n con rayos gamma.<；/p>；
