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Pharmaceutical composition for prevention or treatment of muscular disease comprising Codonopsis lanceolata extract as an active ingredient
专利权人:
JUNG, WOO JAE;정우재
发明人:
정우재,JUNG, WOO JAEKR,JUNG, WOO JAE
申请号:
KR1020190101957
公开号:
KR1020200021434A
申请日:
2019.08.20
申请国别(地区):
KR
年份:
2020
代理人:
摘要:
The present invention relates to a pharmaceutical composition for preventing or treating muscle diseases, which contains the extract of Codonopsis lanceolata as an active ingredient. Specifically, the deodeok extract of the present invention mitigates the decrease in muscle weight and muscle fiber cross-sectional area according to muscle atrophy, and MuRF-1 (Muscle RING-finger protein-1) and atherosine-1 (associated with muscle protein degradation) It may be useful for preventing, ameliorating or treating muscle diseases by alleviating increased expression of atrogin-1) and increasing the expression of phosphorylated mammalian target of rapamycin (p-mTOR) involved in the synthesis of muscle proteins. .본 발명은 더덕(Codonopsis lanceolata) 추출물을 유효성분으로 함유하는 근육 질환의 예방 또는 치료용 약학적 조성물에 관한 것이다. 구체적으로, 본 발명의 더덕 추출물은 근위축에 따른 근육 무게 및 근섬유 단면적의 감소를 완화시키고, 근육 단백질의 분해에 관여하는 MuRF-1(Muscle RING-finger protein-1) 및 아트로진-1(atrogin-1)의 발현 증가를 완화시키며, 근육 단백질의 합성에 관여하는 p-mTOR(phosphorylated mammalian target of rapamycin)의 발현을 증가시킴으로써, 근육 질환을 예방, 개선 또는 치료하는 데 유용하게 이용될 수 있다.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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