Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases
Korea Research Institute of Bioscience and Biotechnology;Daegu-Gyeongbuk Medical Innovation Foundation;Daegu Gyeongbuk Institute of Science and Technology
发明人:
Choi, Hwan Geun,Ko, Eunhwa,Cho, Joong-heui,Son, Jung Beom,Ko, Yi Kyung,Park, Jin-Hee,Kim, So Young,Kang, Seock Yong,Lee, Seungyeon,Ryu, Hee Yoon,Kim, Nam Doo,Kim, Sang Bum,Lee, Sun-Hwa,Kim, Dayea,Lee,
申请号：
AU2018239798
公开号：
AU2018239798A1
申请日:
2018.03.23
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.
