CHEN, YI,CUSHING, TIMOTHY D,DUQUETTE, JASON A,GONZALEZ LOPEZ DE TURISO, FELIX,HAO, XIAOLIN,HE, XIAO,LUCAS, BRIAN,MCGEE, LAWRENCE R,REICHELT, ANDREAS,RZASA, ROBERT M,SEGANISH, JENNIFER,SHIN, YOUNGSOOK
申请号：
NZ57983408
公开号：
NZ579834A
申请日:
2008.03.24
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed are phosphatidylinositol 3-kinase (PI3K) inhibitor compounds having the depicted formula, salts thereof, and methods for their preparation. Specific examples of the compounds include (3S)-3-(8-chloro-2-(2-chlorophenyl)-3-quinolinyl)-3-(9H-purin-6-ylamino)-1-propanol, 1-(8-chloro-3-((9H-purin-6-ylamino)methyl)-2-quinolinyl)-3-piperidinol, 2-(3-fluorophenyl)-3-((1S)-1-(9H-purin-6-ylamino)ethyl)-8-quinolinecarbonitrile, and 2-(3-fluorophenyl)-3-((9H-purin-6-ylamino)methyl)-8-quinolinecarbonitrile Also disclosed is the use of the PI3K inhibitor compounds for treating cancer, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, psoriatic arthritis, psoriasis, inflammatory diseases and autoimmune diseases, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, skin complaints with inflammatory components, chronic inflammatory conditions, autoimmune diseases, systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions and hypersensitivity.
