The invention relates to methods for treating of tumor metastasis, methods forpreventing, inhibiting, and predictingtumor recurrence and tumor metastasis, and methods of preventing cancerdevelopment for one at risk of developing cancer, for onediagnosed with a benign cancer, and/or for one diagnosed with malignantcancer. The invention also relates to methods of treatingangiogenesis-dependent diseases and disorders. In addition, the inventionprovides: (1) a method for screening for tumor/cancerderived angiogenesis and metastasis factors； (2) a method for screening forcompounds that inhibit angiogenesis and metastasis； (3) amethod for screening for compounds that promote anti- angiogenesis and anti-metastasis activities； (4) a method for cancer prognosisevaluation； (5) a method for predicting the tissue specificity of ametastastic cancer； (6) a method for determining likelihood ofmetastasis； and (7) a method for cancer prognosis evaluation by thesurveillance of metastasis development.
