SON, JONG HWA,손종화,HONG, MIN,홍민,YOO, HAN CHEOL,유한철,SON, JONG HWAKR,HONG, MINKR,YOO, HAN CHEOLKR
申请号：
KR1020130032385
公开号：
KR1020140117215A
申请日:
2013.03.26
申请国别(地区):
KR
年份:
2014
代理人:
摘要：
The present invention relates to a manufacturing method for a nanobubble mixed organ preserving solution comprising: (a) a step of mixing sodium chloride with ultrapure water obtained by purifying raw water through a filtering process of three steps of an ultrafilter, an ion filter and electrodeionization (EDI)； (b) a step of generating nanobubbles in high pressure conditions by applying oxygen to a mixed solution； (c) a step of manufacturing nanobubble mixed base water by removing ionic materials and sodium ions by passing a nanobubble mixed solution through an ultrafilter and an ion filter； (d) a step of mixing an raw organ preserving material and the base water manufactured in step (c)； (e) a step of adding the base water manufactured in step (c) to a mixture of step (d)； and (f) a step of mixing nanobubbles in high pressure conditions by applying oxygen and carbon dioxide to a mixed solution of step (e), and to a manufacturing apparatus for a nanobubble mixed organ preserving solution. The manufacturing apparatus for an organ preserving solution according to the present invention facilitates process working since a manufacturing process and apparatus washing are performed at the same time by installing a clean-in-place (CIP) device. An organ preserving solution manufactured by the manufacturing process is useful in medical industry fields by eminently increasing the effects of compositions with ischemia-reperfusion preventing effects clinically used in the conservation of a transplantable organ by nanobubbles.본 발명은 (a) 원수를 울트라필터, 이온필터 및 탈이온(Electrodeionization, EDI)의 3 단계의 여과과정을 통해 정제시킨 초순수에 염화나트륨을 혼합하는 단계； (b) 상기 혼합액에 산소를 가하여 고압상태에서 나노버블을 생성하는 단계； (c) 상기 나노버블 혼입액을 울트라필터 및 이온필터에 통과시켜 이온성 물질과 나트륨 이온을 제거하여 나노버블이 혼입된 베이스 워터를 제조하는 단계； (d) 장기 보존액 원료와 (c) 단계에서 제조된 베이스 워터를 혼합하는 단계； (e) (d)의 혼합물에 (c) 단계에서 제조된 베이스 워터를 추가하는 단계； 및 (f) (e)의 혼합액에 산소 및 이산화탄소를 가하여 고압상태에서 나노버블이 혼입되도록 하는 단계를 포함하는 것을 특징으로 하는 이식용 장기 보존액의 제조 방법 및 장치에 관한 것이다. 본 발명에 따른 이식용 장기 보존액 제조 장치에는 CIP(Clean-
