A method for reducing blood glucose and improving glucose tolerance, comprising administering an effective amount of plasminogen to a diabetic subject. Also involved is a drug for reducing blood glucose and improving glucose tolerance.本發明涉及一新的降血糖和提高糖耐量的方法,包括給藥糖尿病受試者有效量的纖溶酶原,同時本發明涉及用於降血糖和提高糖耐量的藥物。