Provided herein are peptides and analogs of INGAP and HIP peptides and modifications thereof. Also provided herein are said peptides, analogs or modifications thereof for use in methods of treating various diseases and conditions including impaired pancreatic function and metabolic diseases, for example, diabetes (types 1 and 2). The uses also include islets induction, expansion and proliferation for transplantation, promoting neuroprotection or nerve regeneration, promoting liver regeneration or inhibition inflammation.
