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Melt-extruded solid dispersions containing an apoptosis-inducing agent
专利权人:
ABBVIE BAHAMAS LTD.;ABBOTT GMBH & CO. KG
发明人:
LINDLEY DAVID J.,TONG PING,RÖSCH ESTHER,HOELIG PETER,SANZGIRI YESHWANT D.
申请号:
NZ60890711
公开号:
NZ608907A
申请日:
2011.10.05
申请国别(地区):
NZ
年份:
2015
代理人:
摘要:
The disclosure relates to a pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of formula (I) as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises subjecting to elevated temperature the compound of formula (I), the water-soluble polymeric carrier and the surfactant, to provide an extrudable semi-solid mixture; extruding the semi-solid mixture; and cooling the resulting extrudate to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer or an immune or autoimmune disease.
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