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Melt-extruded solid dispersions containing an apoptosis-inducing agent
专利权人:
AbbVie Ireland Unlimited Company
发明人:
HOELIG, Peter,LINDLEY, David J.,SANZGIRI, Yeshwant D.,TONG, Ping,RÖSCH, Esther
申请号:
DK11770975
公开号:
DK2613769T3
申请日:
2011.10.05
申请国别(地区):
DK
年份:
2018
代理人:
摘要:
A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises subjecting to elevated temperature the compound of Formula I, the water-soluble polymeric carrier and the surfactant, to provide an extrudable semi-solid mixture; extruding the semi-solid mixture; and cooling the resulting extrudate to to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer or an immune or autoimmune disease.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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