BEASLEY, MATTHEW DAVID,NIVEN, KEITH PHILIP,KIEFEL, BEN ROSS
申请号：
CA2845391
公开号：
CA2845391A1
申请日:
2012.08.17
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention relates generally to polypeptides, such as antibody molecules, that demonstrate high stability and solubility. In particular, the invention relates to polypeptides comprising paired VL and VH domains that demonstrate soluble expression and folding in a reducing or intracellular environment. The invention also relates to polynucleotides encoding such polypeptides, to libraries of such polypeptides or polynucleotides, and to methods of using such polypeptides in research, diagnostic and therapeutic applications.
