The present invention discloses a pressure-depending clutching device for locating and safely positioning a needle in a body cavity. The device is capable of automatically engaging and disengaging the needle from a driving force depending on the pressure experienced by needle. The device has a body with an interior space, a pressure-sensing element disposed in the body defining a portion of a pressure chamber, and a force-receiving element operatively connected to the pressure-sensing element. The force-receiving element has a shape complimentary to a portion of a force-sending element operatively connected to a force-applying structure such as a handle for a user to apply a driving force. The pressure-sensing element, the force-receiving element, and the complementary force-sending element form a driving force engaging mechanism for coupling the force-applying structure to the needle during operation. Before the needle reaches the target body cavity, the pressure in the needle causes the clutching device to assume an “engaged” state, coupling the driving force to the needle. When the needle reaches the body cavity, the change in pressure causes the clutching device to assume a “disengaged” state, disengaging the driving force from the needle, thereby, automatically positioning the needle in the cavity to avoid overshooting. Also provided are needle-and-syringe assemblies incorporating the disclosed clutching devices, methods for manufacturing the disclosed clutching devices, as well as methods for safely locating and positioning needles in the body cavity utilizing a needle-and-syringe assembly incorporating the disclosed clutching devices.