DANILET VI A. MUNCAL,NADIA MAE CAJUCOM,MA. GRACIELE E. PLACIDO
申请号：
PH12015000305
公开号：
PH12015000305A1
申请日:
2015.09.10
申请国别(地区):
PH
年份:
2017
代理人:
摘要：
The present invention relates to the development of berberine-PVA gel patch and assessment of its microbial inhibiting and wound healing activity. Formation of an N-O bond facilitates the bonding between berberine and PVA as confirmed by FTIR analysis. The best ratio of berberine-PVA gel patch was determined to be 4 pcnt (w/v) that exhibit inhibiting activity against gram positive bacteria Staphylococcus aureus and fungi Candida albicans. The percentage wound closure at 10 days for the different treatment groups were as follows: 92.18 pcnt for the berberine-PVA gel treated animals, 51.9 pcnt for the PVA-gel treated animals and 81.24 pcnt for the positive control. Moreover, bacterial count for berberine-PVA gel was observed to decrease greatly compared with that of the positive control. These findings suggest that berberine-PVA gel patch could be an alternate patch with wound healing activity against gram positive bacteria and fungi comparable with conventional patch available in the market.
