HARTMANN, GUNTHER, PROF. DR.,SCHLEE, MARTIN, DR. RER. NAT.
申请号：
DK12004666
公开号：
DK2518150T3
申请日:
2008.05.21
申请国别(地区):
DK
年份:
2015
代理人:
摘要：
The present invention provides an oligonucleotide which is capable of activating RIG-I and inducing an anti-viral, in particular, an IFN, response in cells expressing RIG-I. The oligonucleotide of the present invention has a double-stranded section of at least 21bp, at least one 5' triphosphate, and at least one blunt end which bears a 5' triphosphate. The present invention further provides the use said oligonucleotide for inducing an anti-viral, in particular, an IFN, response in vitro and in vivo. The present invention additionally provides the use of said oligonucleotide for preventing and/or treating diseases or conditions such as infections, tumors/cancers, and immune disorders.
