5 'triphosphate oligonucleotide having blunt ends and uses thereof

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专利权人:

ライニッシュ;フリードリッヒ－ウィルヘルムズ－ユニバーシタット;ライニッシュ フリードリッヒ-ウィルヘルムズ-ユニバーシタット ボン;ボン

发明人:

ハートマン ガンサー,シュリー マーティン

申请号：

JP2011509895

公开号：

JP5689413B2

申请日:

2009.05.20

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

The present invention provides an oligonucleotide which is capable of activating RIG-I and inducing an anti-viral, in particular, an IFN, response in cells expressing RIG-I. The present invention further provides an oligonucleotide which is capable of activating RIG-I and which has target gene-silencing activity. The oligonucleotide of the present invention has a double-stranded section of at least 19, preferably at least 21 bp, at least one 5′ triphosphate, and at least one blunt end which bears a 5′ triphosphate. The present invention further provides the use said oligonucleotide for inducing an anti-viral, in particular, an IFN, response in vitro and in vivo. The present invention additionally provides the use of said oligonucleotide for preventing and/or treating diseases or conditions such as infections, tumors/cancers, and immune disorders.

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中国工程科技知识中心

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