Disclosed is a pharmaceutical composition comprising a solid unit dosage form comprising: (i) Ritonavir or a pharmaceutically acceptable salt thereof； (ii) Atazanavir or a pharmaceutically acceptable salt thereof. Which is a tablet formulation comprising said ritonavir in a first layer of the formulation and said atazanavir in a second layer of the formulation, and further comprising a water insoluble polymer and/or a water soluble polymer. Further disclosed is use of said composition in the manufacture of a medicament for treating HIV or AIDS. Also disclosed is a method for making said composition.
