PROBLEM TO BE SOLVED: To provide a laminin 5 production promoter, an integrin α6β4 production promoter, a skin basement membrane-normalizing agent, a skin damage-restoring promoter or an aquaporin 3mRNA expression promoter which contains, as an active ingredient, a substance which has laminin 5 production-promoting action, integrin α6β4 production-promoting action or aquaporin 3mRNA expression-promoting action, the substance being found from a natural product which is high in safety.SOLUTION: The laminin 5 production promoter, the integrin α6β4 production promoter, the skin basement membrane-normalizing agent, the skin damage-restoring promoter or the aquaporin 3mRNA expression promoter includes, as an active ingredient, an extract from Alpinia zerumbet.COPYRIGHT: (C)2013,JPO&INPIT【課題】安全性の高い天然物の中からラミニン5産生促進作用、インテグリンα6β4産生促進作用又はアクアポリン3mRNA発現促進作用を有するものを見出し、それを有効成分とするラミニン5産生促進剤、インテグリンα6β4産生促進剤、皮膚基底膜正常化剤、皮膚損傷回復促進剤又はアクアポリン3mRNA発現促進剤を提供する。【解決手段】本発明のラミニン5産生促進剤、インテグリンα6β4産生促進剤、皮膚基底膜正常化剤、皮膚損傷回復促進剤又はアクアポリン3mRNA発現促進剤の有効成分として、月桃からの抽出物を含有させる。【選択図】なし
