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Izboljšano humanizirano anti-humano alfa9-integrinsko protitelo
专利权人:
ASTELLAS PHARMA INC.
发明人:
UEHARA KENJI,HIGUCHI HIROFUMI,NAKASHIMA TOSHIHIRO,ISHIKAWA DAISUKE,YAMAMOTO NOBUCHIKA,FUJITA HIROTADA,SAKAI FUMIHIKO,UEHARA Kenji,HIGUCHI Hirofumi,NAKASHIMA Toshihiro,ISHIKAWA Daisuke,YAMAMOTO Nobuchika,FUJITA Hirot
申请号:
SI200931034
公开号:
SI2243829T1
申请日:
2009.01.09
申请国别(地区):
SI
年份:
2014
代理人:
摘要:
The present invention provides a humanized anti-human ±9 integrin antibody having improved activity and/or property as compared to donor mouse anti-human ±9 integrin antibody, namely, a humanized anti-human ±9 integrin antibody comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 1 or the amino acid sequence shown by SEQ ID NO: 1 wherein one or several amino acids are substituted, deleted, inserted and/or added and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 61 or the amino acid sequence shown by SEQ ID NO: 61 wherein one or several amino acids are substituted, deleted, inserted and/or added, as well as a means for preventing or treating various diseases involving human ±9 integrin in their pathogenesis, which uses the antibody.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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