BANDO TAKUJI,YANO KATSUHIKO,FUKANA MAKOTO,AOKI SATOSHI
申请号：
NZ62042912
公开号：
NZ620429A
申请日:
2012.06.29
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed herein is a method for producing fine particles of aripiprazole anhydride crystals B less than 50 µm in size, comprising the steps of: (a) heating and dissolving crude aripiprazole in a lower alcohol selected from the group consisting of methanol and ethanol, and subsequently cooling the resulting mixture to precipitate crystals to obtain crystals of aripiprazole lower alcohol solvate (b) subjecting the crystals of aripiprazole lower alcohol solvate to wet-milling in the form of a slurry containing the lower alcohol and (c) subjecting the dispersion of the wet-milled crystals to solid-liquid separation to obtain the crystals, and heating the crystals to dry. In one embodiment the volume average particle size of the wet-milled crystals in step (b) is 15 to 20 µm. Aripiprazole is known as 7-{ 4-[4-(2,3-dichlorophenyl)-I-piperazinyl]butoxy} -3,4-dihydrocarbostyril or 7-{ 4-[4-(2,3-dichlorophenyl)-Ipiperazinyl]butoxy} -3,4-dihydro-2(IH)-quinolinone.
