The disclosure provides a hemostatic compound, the hemostatic compound comprises molecular sieves and a fiber, and the molecular sieves are distributed on the fiber surface of the fiber and directly contact the fiber surface. The particle diameter D90 of the molecular sieves is 0.01 to 50 µm, the particle diameter D50 of the molecular sieves is 0.005 to 30 µm. The adhesive content of the contact surface between the molecular sieve and the fiber is zero. The surface of molecular sieve contacted with the fiber is an inner surface, and the inner surface is a rough planar surface, and growth-matched coupling is formed between the molecular sieve and the fiber on the inner surface of the molecular sieve. The surface of molecular sieve uncontacted with the fiber is an outer surface, and the outer surface is non-planar surface. Both the inner surface and outer surface are composed of molecular sieve nanoparticles. The disclosure also provides a preparation method and application of the hemostatic compound. The hemostatic compound of the present disclosure does not need to add an adhesive. And it speeds up the coagulation reaction and plays a role of rapid coagulation, and eliminates the problem that the molecular sieve easily falls off the fiber surface, eradicates the problem that the hemostatic compound easily loses the hemostatic effect, solves the problem that some detachable molecular sieves will adhere to the wound and cause thrombosis, and finally improves the performance and safety of the hemostatic compound.
