ROHLOFF, CATHERINE MANYA,罗凯萨,羅凱薩,CHEN, GUOHUA,陈国华,陳國華,DING, ZHONGLI,丁中立,丁中立,BERRY, STEPHEN ANDREW,巴安卓,巴安卓,NARAYANAN, LATHA PISHARODY,那罗亚,那羅亞,DESJARDIN, MICHAEL A.,戴麦克,戴麥克
申请号：
TW095122472
公开号：
TWI398270B
申请日:
2006.06.22
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
Formulations and methods are provided for improving the stability upon exposure to aqueous media of polypeptideS present in non-aqueous suspension vehicles. In particular aspects of the invention,formulations are provided that comprise a complex of a metal ion and a polypeptide suspended in a non-aqueous, biocompatible suspension vehicle. Aggregation of individual polypeptide molecules is reduced when aqueous media is introduced to such formulations, serving to stabilize the polypeptide.提供用於當存在懸浮於非水性懸浮媒劑內之多肽暴露於水性介質時改善穩定性的配製物及方法。在本發明的特定方面中,提供包含懸浮於非水性生物相容懸浮媒劑內之金屬離子和多肽複合物的配製物。當水性介質被引入此類配製物時個別多肽分子的凝聚作用減少,以用作為穩定該多肽。
