The present invention relates to an immunomodulatory composition comprising a yolk product from eggs laid by female poultry which has been immunized withHelicobacter pylori. The immunomodulatory composition of the invention is effective in modulating an immune response in a subject. In particular, the immunomodulatory composition can promote production of IFN-γ and inhibit production of IL-4 and IL-5 in a subject.本發明係關於一種免疫調節組合物,其包括來自經幽門螺旋桿菌(Helicobacter pylori)致免疫之雌性家禽所產下之蛋之蛋黃產物。本發明之免疫調節組合物可調節個體之免疫反應。具體而言,該免疫調節組合物可在一個體中促進IFN-γ之產生及抑制IL-4與IL-5之產生。