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ALKILAMIN-SUPSTITUIRANI DICIJANOPIRIDIN I NJEGOVI ESTERSKI AMINO KISELINSKI PREDLIJEKOVI
专利权人:
BAYER INTELLECTUAL PROPERTY GMBH
发明人:
VAKALOPOULOS, ALEXANDROS,MEIBOM, DANIEL,ALBRECHT-KÜPPER, BARBARA,ZIMMERMANN, KATJA,KELDENICH, JOERG,LERCHEN, HANS-GEORG,NELL, PETER,SÜSSMEIER, FRANK,KRENZ, URSULA
申请号:
HRP20140714
公开号:
HRP20140714T1
申请日:
2014.07.24
申请国别(地区):
HR
年份:
2014
代理人:
摘要:
Alkylamino-substituted dicyanopyridine compounds (I) and their salts, N-oxides, solvates, salts of N-oxide or solvates of N-oxide and salts are new. Alkylamino-substituted dicyanopyridine compounds of formula (I) and their salts, N-oxides, solvates, salts of N-oxide or solvates of N-oxide and salts are new. Either R 1>; : H or (1-4C)-alkyl; and R 2>; : (1-6C)-alkyl, (2-4C)-alkenyl, (2-4C)-alkynyl or (3-7C)-cycloalkyl, where: (1-6C)-alkyl is optionally substituted by 1-3 F, Cl, CF 3, CF 3O, (1-4C)-alkoxy, (3-7C)-cycloalkyl, (3-7C)-cycloalkoxy, (1-4C)-alkylsulfanyl or (1-4C)-alkylsulfonyl, (2-4C)-alkenyl and (2-4C)-alkynyl is optionally substituted by 1 or 2 F, CF 3, (1-4C)-alkyl, CF 3O or (1-4C)-alkoxy, and (3-7C)-cycloalkyl is optionally substituted by 1 or 2 F, Cl, CF 3, (1-4C)-alkyl, CF 3O or (1-4C)-alkoxy; or R 1>;R 2>;N : 4-7-membered heterocycle optionally substituted by 1 or 2 F, Cl, oxo, CF 3, (1-4C)-alkyl, CF 3O or (1-4C)-alkoxy; R 3>; : H, -C(=O)-C(R 4>;)(R 5>;)-N(R 7>;)(R 6>;) (A), -C(=O)-C(R 8>;)(R 9>;)-N(R 10>;)-C(=O)-C(R 11>;)(R 12>;)-N(R 13>;)(R 14>;) (B), -C(=O)-C(R 8>;)(R 9>;)-N(R 10>;)-C(=O)-L 1>;-N(R 15>;)(R 16>;) (C), -C(=O)-L 2>;-N(R 16>;)(R 17>;) (D), -C(=O)-L 2>;-N(R 19>;)-C(=O)-C(R 11>;)(R 12>;)-N(R 13>;)(R 13>;) (E) or -C(=O)-L 2>;-N(R 19>;)-C(=O) -L 1>;-N(R 15>;)(R 16>;) (F); L 1>;, L 2>; : (2-6C)-alkanediyl; either R 4>;, R 8>; : H or the side group of a natural amino acid or its homologous or isomer; and R 6>;, R 7>;, R 13>;-R 18>; : H or (1-4C)-alkyl; or R 6>;R 7>;N, R 13>;R 14>;N, R 15>;R 16>;N, R 17>;R 18>;N : a 5- or 6-membered heterocycle optionally substituted by 1 or 2 (1-4C)-alkyl, amino, OH or (1-4C)-alkoxy; or R 7>;R 4>; : pyrrolidine- or piperidine ring; R 5>;, R 9>;, R 10>;, R 12>;, R 19>; : H or CH 3; and either R 11>; : H or a side group of a natural alpha -amino acid or its homologous or isomer; or R 14>;
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