PROBLEM TO BE SOLVED: To provide a novel composition which can inhibit an epithelial or mucosal deficiency associated with Th17 cells.SOLUTION: The composition which is administered to an epithelium or mucosa contains as an active ingredient (i) a polypeptide consisting of an amino acid sequence comprising Cys-Gly-Pro-Cys, or (ii) a substance which topically facilitates the production of endogenous thioredoxin protein and is used for topically inhibiting the production or secretion of Th17 type cytokine, or for treating or preventing skin diseases attributed to or associated with Th17 cell.SELECTED DRAWING: Figure 3COPYRIGHT: (C)2016,JPO&INPIT【課題】Th17細胞に関わる上皮又は粘膜の不具合を抑制することができる新規な組成物の提供。【解決手段】上皮又は粘膜に投与される組成物は、(i)Cys-Gly-Pro-Cysを含むアミノ酸配列からなるポリペプチド、又は(ii)内在性チオレドキシンタンパク質の生産を局所的に亢進する物質を有効成分として含有し、Th17型サイトカインの生産又は分泌を局所的に抑制するため、又はTh17細胞に起因又は関連する皮膚疾患の治療または予防に用いられる。【選択図】図3
