Travins, Jeremy,Yan, Shunqi,Popovici-Muller, Janeta,Salituro, Francesco Gerald,Saunders, Jeffrey Owen
申请号：
NZ70699913
公开号：
NZ706999A
申请日:
2013.10.11
申请国别(地区):
NZ
年份:
2018
代理人:
摘要：
Provided are aryl sulfonamide diarylurea derivative compounds that are inhibitors of mutant isocitrate dehydrogenase 1/2 (IDH 1/2), useful for treating cancer. Also provided are methods of treating cancer comprising administering to a subject in need thereof a compound described herein. Cancers that are treatable by the compounds of the invention are glioblastoma, myelodysplastic syndrome, myeloproliferative neoplasm, acute myelogenous leukemia, sarcoma, melanoma, non-small cell lung cancer, chondrosarcoma, and non-Hodgkin’s lymphoma (NHL).
