Does this invention, although (a) the melatonin, the other melatonin operation medicine, at least one which is selected from meratoninagonisuto and the melatonin antagonist 1st active ingredient and, (b) it remedies the insomnia patient who at least includes with one which is selected from nicotine and nicotine receptor agonisuto 2nd active ingredient, the usefulness is brought to the patient with process of combination and the nicotine supplement medical therapy which are effective pharmacology, the component in order at least to lighten one which is selected from decrease of quality of sleep and acknowledgment obstacle and dysmnesia side effect (a) includes, the component (b) include? Although the component (a) and (b) it remedies the insomnia patient who is included while using, and unit dosage form of the medical supply which is not included it regards the useful kit.本発明は、(a)メラトニン、他のメラトニン作動薬、メラトニンアゴニストおよびメラトニンアンタゴニストから選択される少なくとも1つの第1の有効成分と、(b)ニコチンおよびニコチン受容体アゴニストから選択される少なくとも1つの第2の有効成分とを含む不眠症患者を治療するのに有用な薬理学的に有効な組合せ、ニコチン補充療法の過程で患者にもたらされるか、あるいは、睡眠の質の低下、認知障害および記憶障害から選択される少なくとも1つの副作用を軽減するための、成分(a)を含み、成分(b)を含むか含まない医薬品の使用、ならびに単位投与形態中に成分(a)および(b)を含む不眠症患者を治療するのに有用なキットに関する。
