MATHES, CHRISTIAN,FOULKES, MICHAEL,KESSELGRUBER, MARTIN
申请号:
MYPI 2011002891
公开号:
MY151103A
申请日:
2009.12.23
申请国别(地区):
MY
年份:
2014
代理人:
摘要:
A CATALYTIC PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE COMPOUNDS AND THEIR CONVERSION THEREAFTER TO DESIRED DRUG SUBSTANCES. IN PARTICULAR, THE PROCESS RELATES TO THE PREPARATION OF (S)-3-(1-DIMETHYLAMINO-ETHYL)-PHENOL USING ASYMMETRIC CATALYTIC REDUCTION AND TRANSFER HYDROGENATION, THEREBY PROVIDING AN IMPROVED ROUTE TO FORMING DRUG SUBSTANCES SUCH AS RIVASTIGIMINE AND RIVASTIGIMINE HYDROGEN TARTRATE.