Christian Mathes,Michael Foulkes,Martin Kesselgruber
申请号：
US13705884
公开号：
US08637713B2
申请日:
2012.12.05
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A catalytic process for the preparation of optically active compounds and their conversion thereafter to desired drug substances. In particular, the process relates to the preparation of (S)-3-(1-Dimethylamino-ethyl)-phenol using asymmetric catalytic reduction and transfer hydrogenation, thereby providing an improved route to forming drug substances such as rivastigimine and rivastigimine hydrogen tartrate.
