KWON, BYOUNG S.,LEE, SEOUNG-JOO,KIM, YOUNG HO,OH, HO-SIK,LEE, JOONG WON
申请号：
CA3039772
公开号：
CA3039772A1
申请日:
2018.01.05
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Provided are anti-human 4-1BB antibodies and fragments thereof with one or more structural features that are not found in a reference anti-human 4- 1BB antibody, where said features may improve certain characteristics of the antibody relative to a reference antibody. Various in vitro and in vivo methods and reagents related to anti-human 4-1BB antibodies described herein are also provided. Methods include, for example, inducing T-cell proliferation, inducing T cell secretion of IFN?, as well as detection, prevention, and/or therapeutic treatment of cancer using an anti-human 4-1BB antibody or fragment thereof.
