Byoung S. Kwon,Seoung-Joo Lee,Young Ho Kim,Ho-Sik Oh,Joong Won Lee
申请号：
US16790299
公开号：
US10774151B2
申请日:
2020.02.13
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided are anti-human 4-1BB antibodies and fragments thereof with one or more structural features that are not found in a reference anti-human 4-1BB antibody, where said features may improve certain characteristics of the antibody relative to a reference antibody. Various in vitro and in vivo methods and reagents related to anti-human 4-1BB antibodies described herein are also provided. Methods include, for example, inducing T-cell proliferation, inducing T cell secretion of IFNγ, as well as detection, prevention, and/or therapeutic treatment of cancer using an anti-human 4-1BB antibody or fragment thereof.
