An apparatus, system, and method are disclosed for isolating and venting a litter box. The apparatus includes an enclosure for a litter box, an access door and a pet door in the enclosure, at least one vent between an interior and an exterior of the enclosure, and an exit duct between the interior and the exterior of the enclosure. The system includes a pet enclosure having an enclosure door, a pet door, at least one vent, and at least one exhaust duct, a litter box adapted for placement in the enclosure, a motor and fan in fluid communication with the exit duct, and a conduit from the exit duct adapted for fluid connection to an exterior of a house. The method includes enclosing a litter box in a pet container, drawing outside air through at least one vent in the pet container into an interior of the pet container and exhausting air from the pet container out through an exit duct.