Devices, systems, and methods for evaluating patient vasculature are provided. In some instances, the methods can include obtaining external imaging data associated with at least one of a vessel and a heart； obtaining physiology data associated with the vessel； obtaining intravascular imaging data associated with the vessel； co-registering the physiology data and the intravascular imaging data with the external imaging data； generating a three-dimensional graphical representation of the at least one of the vessel and the heart based on the external imaging data, the physiology data, and the intravascular imaging data； and outputting the graphical representation of the at least one of the vessel and the heart to a display device, wherein the graphical representation includes a first indicator associated with a location within the vessel of the co-registered physiology data and a second indicator associated with a location within the vessel of the co-registered intravascular imaging data.
