This application relates to compounds with pharmacological activity against both the Dual receiver Sigma (S) such as opioid receptor M and more particularly to diazaspiroundecano compounds with pharmacological activity, processes for preparing such Compounds, composition Pharmaceutical ones containing same and their use in therapyIn particular, for the treatment of pain.Claim 1: Compound of formula (1) and is a compound of formula (2), (3) or (4); Z is - ch u2082 -, - C (o) - O - chr u2079; M is 0 OR 1; n is 1, 2 or 3; Q is 1, 2 3, 4, 5 or 6; r u00b9 is aryl substituted or unsubstituted, heterociclilo replaced or not replaced or not replaced, alkylaryl Structures, alquilheterociclilo replaced or not replaced or - (ch u2082) u02b3 - W - r u00b9 -; R is 0, 1 or 2; W is a Link, ch u2082o -- ch u2082c (OR) nr u2075 -, - or - ch u2082c (OR), ch u2082c - (OR) - or - C (ch u2083) u2082o; r u00b9 is H, - CN, heterociclilo replaced or not replaced, substituted or unsubstituted cycloalkyl substituted aryl, substituted or unsubstituted or r u2075; in which the aryl, in heterociclilo or cycloalkyl substituted r u00b9 r u00b9 or, if they are also to Lquilarilo or alquilheterociclilo are substituted with substituents selected from r u2075 or u2075 -, -, - CN, halogenNo u2082 nr u2075r u2075 -, -, - C (o) or u2075, nr u2075c (OR) r u2075, - C (o) - nr u2075s nr u2075r u2075, (OR) u2082r u2075, =, or - och u2082ch u2082oh, nr u2075c nr u2075r u2075, (OR) - S (o) - nr u2075s u2082nr u2075r u2075, (OR) u2082nr u2075r u2075, haloalquilo, haloalcoxi, - sr u2075 - s or - S (o) r u2075 (OR) u2082r u2075; X is a Link, - C (o) o -, - C (o) nr u2075 -, - C (o) -, - or - or - C (r u2074r u2074) - R u00b2 is h; Aryl, substituted or non substituted or unsubstituted cycloalkyl substituted heterociclilo, substituted or unsubstituted alkyl, substituted or non substituted c u2081 u208b u2086,Alquenilo c u2082 u208b u2086 replaced or not replaced or alquinilo c u2082 u208b u2086 replaced or n