Methods, apparatus, systems and articles of manufacture are disclosed to generate an interface definition based on role, exam terms, and rules. An example apparatus includes at least one processor to at least: trigger rule generation based on an identified role and a primary exam; extract terms from the primary exam; process the extracted terms and identified role according to a first set of rules to generate a first lab panel display in an interface; facilitate i) rule editing and/or ii) rule generation to form a second set of rules using the extracted terms and identified role; apply the second set of rules to: i) modify the first lab panel display; and/or ii) generate a second lab panel display; generate an interface definition based on the first lab panel display and the second lab panel display; and provide the interface definition as output for display and interaction.