Polymorphic Compound (S) - 3 - (1 - (9H purin - 6 - ilamino) ethyl) - 8 - 2 - chlorine - fenilisoquinolin - 1 - (2H) - one of forms B J, Amorphous, Salt, hydrate or solvate thereof; mixtures of these Compounds, method for preparing the Polymorph Pharmaceutical Composition of c;; Treatment method; use for Treatment (d And a disorder mediated by PI3K.
REN PINGDA,MARTIN MICHAEL,ISBESTER PAUL,LANE BENJAMIN S,KROPP JASON
申请号:
CL2013002007
公开号:
CL2013002007A1
申请日:
2013.07.09
申请国别(地区):
CL
年份:
2014
代理人:
摘要:
Polymorphs of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI 3 kinase activity, are described herein. Also provided herein are processes for preparing compounds, polymorphs thereof, and pharmaceutical compositions thereof.FORMA POLIMÓRFICA C DE (S)-3-(1-(9H-PURIN-6-ILAMINO)ETIL)-8-CLORO-2-FENILISOQUINOLIN-1(2H)-ONA; MÉTODO DE PREPARACIÓN; COMPOSICIÓN FARMACÉUTICA; Y SU USO PARA TRATAR TRASTORNOS MEDIADOS POR PI3K, TALES COMO UNA ENFERMEDAD INFLAMATORIA O AUTOINMUNE.