CRYSTALLINE FORMS OF HYDROCHLORIDE SALT OF (4A-R,9A-S)-1-(1H-BENZOIMIDAZOLE-5-CARBONYL)-2,3,4,4A,9,9A-HEXAHYDRO-1H-INDENO &Scaron2,1-B&CacutePYRIDINE-6-CARBONITRILE AND THEIR USE AS HSD 1 INHIBITORS

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专利权人:

BOEHRINGER INGELHEIM INTERNATIONAL GMBH

发明人:

ECKHARDT MATTHIAS,ECKHARDT Matthias,MARTIN HANS-JUERGEN,MARTIN Hans-Juergen,SCHUEHLE MARTIN,SCHUEHLE Martin,SICK SANDRA,SICK Sandra,YANG BING-SHIOU,YANG Bing-Shiou

申请号：

SI201130449

公开号：

SI2635563T1

申请日:

2011.11.04

申请国别(地区):

SI

年份:

2015

代理人:

摘要：

The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11&bgr-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.

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