Provided herein are compounds, compositions and methods for the treatment of liver disorders, including HCV infections. In one embodiment, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.本發明提供用於治療包括HCV感染之肝臟病症的化合物、組合物及方法。在一實施例中,本發明揭示核苷衍生物之化合物及組合物,其可單獨投與或與其他抗病毒劑組合投與。