Provided herein are compounds, compositions and methods for the treatment of liver disease and conditions, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.本發明提供用於治療肝臟疾病及病況(包括HCV感染)的化合物、組成物及方法。於某些實施態樣中,揭示了核苷衍生物的化合物及組成物,彼等可單獨投藥或與其他抗病毒劑一起合併投藥。