Present disclose provides the bispecifics for including diphtheria toxin (DT) molecule to orient toxin (BLT), and the diphtheria toxin molecule is mutated to generate the DT molecule for inducing less immune response than natural diphtheria toxin.Immune DT molecule is gone merge with targeting ligand this to generate and alternative deliver this and go that fusion protein of the DT to target cell to kill the target cell is immunized.
