DEIMMUNIZED THERAPEUTIC COMPOSITIONS AND METHODS

• 收藏
• 分享

专利权人:

REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人:

VALLERA, DANIEL ATTILIO

申请号：

CA3000756

公开号：

CA3000756A1

申请日:

2016.09.30

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

This disclosure provides a bispecific ligand directed toxin (BLT) that includes a diphtheria toxin (DT) molecule that has been mutated to create a DT molecule that induces less of an immune response than native diphtheria toxin. The deimmunized DT molecule is fused with targeting ligands to create a fusion protein that can selectively deliver the deimmunized DT to target cells to kill the target cells.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/