Embodiments described herein include apparatus for securing and protecting medical tubes, such as a PICC line, which are inserted at an end into a body of a human or other animal. According to one aspect, a medical tube protective sleeve apparatus is provided with a securing strap to secure the apparatus to the body. A first pad has an opening through which the medical tube can be placed. The first pad is connected to the securing strap so that the first pad may be secured to the body, positioned such that the medical tube may be threaded from an insertion point of the body through the opening of the first pad. A second pad is attached to the first pad and may be used to secure onto the first pad to protect the PICC line and exit site from containments. The second pad further includes a securing pocket to allow longer PICC lines to be tucked away/curled-up to avoid being snagged in clothing or other surfaces.
