UNIVERSITE DE VERSAILLES SAINT-QUENTIN-EN-YVELINES;UNIVERSITE PARIS DESCARTES;ASSISTANCE PUBLIQUE HOPITAUX DE PARIS;INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
The present invention relates to a method for producing platelets from maturemegakaryocytes. More particularly,the invention relates to an ex vivo method for producing platelets, frommature megakaryocytes, said method comprising a step ofsubjecting a suspension of mature megakaryocytes to a flow having a minimalshear rate of 600 s-1 on a solid phase coated withVon Willebrand factor.