Ahmed Abouabdellah,Alistair Lochead,Aude Fayol,Julien Vache,Mourad Saady,Nathalie Chereze,Philippe Yaiche
申请号：
BRPI1013932
公开号：
BRPI1013932A2
申请日:
2010.05.11
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The invention relates to compounds of the general formula (I) where: R2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy, or NR8R9 group； m, n, o and p independently are a number from 0 to 3, provided that 2&nlE；m+n&nlE；5 and that 2&nlE；o+p&nlE；5； A is a covalent bond, an oxygen atom, a C1-6-alkylene group or a —O—C1-6-alkylene group in which the end that is an oxygen atom is bonded to the R1 group and the end that is an alkylene group is bonded to the carbon of the bicyclic compound； R1 is an optionally substituted aryl or heteroaryl group； R3 is a hydrogen or fluorine atom or a C1-6-alkyl or trifluoromethyl group； R4 is an optionally substituted 5-membered heterocyclic compounds； wherein the compounds can be in the state of a base or an acid addition salt. The invention can be used in therapeutics.
