Inhibitors of the EGFR kinase targeting the asymmetric activating dimer interface

• 收藏
• 分享

专利权人:

John Kuriyan

发明人:

John Kuriyan,Xuewu Zhang,Philip Cole

申请号：

US12444914

公开号：

US08242080B2

申请日:

2007.10.15

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The invention provides methods and compositions for the modulation of EGFR activity. In particular, inhibition of EGFR activation through an allosteric mechanism is discloses, as is a method for targeted drug discovery and design based on models of the three dimensional structure of the kinase domains of the protein dimers.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/