VAN EENENNAAM, HANS,VAN ELSAS, ANDREA,MEDEMA, JAN PAUL,LUTJE HULSIK, DAVID
申请号：
CA2973286
公开号：
CA2973286A1
申请日:
2016.01.08
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The disclosure relates to APRIL-binding antibodies, which bind the sameepitope of human APRIL as an antibodyhaving an antigen binding site of hAPRIL.01A. The antibodies of the presentdisclosure comprise specific selections of frameworksequences of the V H and V L domains and have unexpected features incomparison to hAPRIL.01A. The disclosure further relates tocompositions comprising an antibody of the invention and to the medical anddiagnostic uses of the antibodies and compositions.
