Provided is a hollow fiber membrane module that has excellent liquid tightness, high bonding strength in a welding portion, and can be manufactured efficiently. The present invention comprises a hollow fiber membrane bundle (4), a main body case (3) that receives the hollow fiber membrane bundle (4), a membrane fixing layer (5) that fixes the hollow fiber membrane bundle (4) to an inner wall of an end portion of the main body case, and headers (8) and (9) that are attached to a case opening end portion and have an inlet (6) or an outlet (7) for a treatment target liquid. The headers (8) and (9) and the main body case (3) are ultrasonically welded in at least two areas over the entire circumference. A share joint is used as joint design by which a side surface of an outer circumference of the main body case and inner side surfaces of the headers are ultrasonically welded over the entire circumference. A butt joint is used as joint design by which a cross section of the main body case and the inner side surfaces of the headers are ultrasonically welded over the entire circumference.
